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US 2008/0305986 A1Published application
Multimers of Peptides
OwnerKillian Waldemar Conde Fieboes, Birgitte Urs +1inventors
InventorsKillian Waldemar Conde Fieboes, Birgitte Urs, Lars Fogh Iversen
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Abstract
Described are compounds useful for trimerising chemical entities, methods of trimerising chemical entities, and trimerised entities. In one aspect, the entities are peptides.
Claims63
A compound represented by the general formula
- wherein Cx represents a center moiety, which is supporting three independent arms;
- each W independently represents C1-6-alkylene, C1-6-alkyleneoxy, C1-6-alkylene, C2-6-alkenylene, C2-6-alkynylene, hydroxy-C1-6-alkylene, hydroxy-C2-6-alkenylene, C1-6-alkyleneoxy, C2-6-alkenyleneoxy, C2-6-alkanoylene, C2-6-alkenoylene or a bond;
- each R′ is the same or different, and comprises one or more of the group A and optionally one or more of the group B, each R′ starting with A,
- wherein A is
- wherein r is any number from 1-50, and n and m are integers ≧2,
- and wherein B is
- wherein X, V and Z are independently selected from —CR1R2—, C3-8— cycloalkylene, C4-8-cycloalkenylene, -arylene-, -heteroarylene-, -heterocyclylene-, —O—, —S—, NR1, —OCH2CH2O—, —OCH2—, —CH2O—;
- R1 and R2 are independently selected from H, C1-6-alkyl, C2-6-alkenyl, C3-8-cycloalkyl, C4-8-cycloalkenyl, or R1 and R2 can be taken together to form a C2-6-alkylene-bridge, and
- q, k and l are independently selected from 0, 1, 2, 3, 4, 5 or 6, but they are not all simultaneously 0;
- and
- Y is a group suitable for covalent attachment to a peptide.
8 more elements
A compound represented by the following formula:
A polypeptide having the sequence of any of SEQ ID NOS:1-7.
(canceled)
Dependencies are inferred from the claim text.