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OwnerHans-George Frank, Karsten Knorr +2inventors
InventorsHans-George Frank, Karsten Knorr, Uda Haberl, Andread Rybka
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A method of generating an isosteric structure of a polypeptide at least partially containing D-amino acids from 3D-coordinates and sequence information of an L-configurated precursor having an N-terminal amino group or substituted amino group, a C-terminal carboxy group or a carboxy derivative, a backbone and L-amino acid side chains, and comprising the steps of—at least partially replacing backbone CO groups with NH groups and vice versa,—while keeping the 3D-coordinates of the precursors L-amino acid side chains, the N-terminal amino group or substituted amino group and the C-terminal carboxy group or carboxy derivative fixed.
A method of generating an isosteric structure of a polypeptide at least partially containing D-amino acids from 3D-coordinates and sequence information of an L-configured precursor having an N-terminal amino group or substituted amino group, a C-terminal carboxy group or a carboxy derivative, a backbone and L-amino acid side chains, and comprising
A compound having Formula 7, wherein X1, X2 and X3 are independently selected from CH2, (C═O), O, S, NH, NR, (CHR), or (CR2), and wherein R is an amino group, an alcohol, halogen or any organic residue;
A compound of Formula 10, wherein X1, X2, X3 and X4 are independently selected from CH2, (C═O), O, S, NH, NR, (CHR), or (CR2), and wherein R is an amino group, an alcohol, halogen or any organic residue
A polypeptide comprising at least one D-amino acid and/or artificial amino acid and 5-aminovaleric acid.
A polypeptide of the amino acid sequence:
Dependencies are inferred from the claim text.