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US 2008/0305518 A1Published application
O-Linked Glycoforms Of Polypeptides And Method To Manufacture Them
AssigneeNovo Nordisk HealthCare A/G
InventorsNiels Kristian Klausen, Daniel Rasmussen
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Abstract
The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these.
Claims30
A preparation of a glycoprotein containing a Cys-X1-Ser/Thr-X2-Pro-Cys motif, wherein the serine/threonine is linked to a sugar chain by a Glc-O-Ser/Thr covalent bond, X1 and X2 each represent any amino acid residue and the preparation has a substantially uniform serine/threonine-linked glycosylation pattern.
Dependencies are inferred from the claim text.