Method for identifying a compound that modulates SIR2 protein activity
AssigneeThe Wistar Institute
InventorsRonen Marmorstein, Brandi D. Sanders
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Abstract
The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base exchange site of Sir2 and testing the compound for its ability to modulate the activity of the Sir2 protein. Compositions and methods for preventing or treating diseases or disorders associated with Sir2 are also provided.
Claims8
A method for identifying a compound which modulates the activity of a silent information regulator 2 (Sir2) protein comprising
- a) designing or screening for a compound which binds to at least one amino acid residue of the nicotinamide inhibition and base exchange site of a Sir2 protein, and
- b) testing the compound designed or screened for in (a) for its ability to modulate the activity of the Sir2 protein, thereby identifying a compound that modulates the activity of a Sir2 protein.
Dependencies are inferred from the claim text.