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AssigneeUniversity of Maryland
InventorsSteven D. MUNGER, Nanette I. Steinle, Alan R. Shuldiner, Soren Snitker, Cedrick D. Dotson, Amanda E.T. Elson, Stephen Vigues
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The present invention relates to methods of determining an increased risk of a subject to acquire a trait of an obesity disorder or an obesity disorder, with the method comprising determining the genetic sequence of at least one taste receptor gene in the subject and reviewing the test genetic sequence(s) for the presence of at least one risk allele associated with at least one taste receptor. The presence of at least one difference in the test genetic sequence(s) and the presence of a risk allele associated with the taste receptor(s) may indicate an increased risk of the subject acquiring a trait of an obesity disorder or an obesity disorder.
A method of determining an increased risk of a subject to acquire a trait of an obesity disorder, the method comprising
A method of determining a novel risk allele associated with a trait of an obesity disorder or an obesity disorder, the method comprising:
A method of altering the levels of incretin hormones secreted from enteroendocrine cells, the method comprising administering to the cells a compound that affects the activity of a TAS2R9 taste receptor present on the surface of said enteroendocrine cells, wherein affecting the activity of the TAS2R9 taste receptor will alter the secretion of incretin hormones from the enteroendocrine cells.
Dependencies are inferred from the claim text.