Process For Loading Polymer Particles With Drug
AssigneeBiocompatibles UK Limited
InventorsAndrew Lennard Lewis, Hind Hassan SidAhmed Goreish, Yiqing Tang
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Abstract
The present invention relates to processes for loading microsphere polymer particles with crystallisable drug, in the presence of a crystallisation inhibitor whereby crystallisation of the drug is inhibited. The invention is of particular value for loading polymer beads with paclitaxel, ibuprofen and/or dexamethasone. The polymer is suitably an anionic polyvinyl alcohol polymer.
Claims44
A process in which swellable beads of water-insoluble, oil-insoluble polymer are contacted with a solution of a crystallisable drug in an organic solvent which is capable of penetrating the beads whereby drug is absorbed into the beads, characterised in that the solution further contains a crystal modifier which inhibits crystallisation of the drug.
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A composition comprising swellable beads of water-insoluble, oil-insoluble polymer, a crystallisable drug and a crystal modifier which inhibits crystallisation of the drug wherein the drug and crystal modifier are absorbed into the beads and the polymer is crosslinked polyvinyl alcohol.
Dependencies are inferred from the claim text.