Sustained release oral formulation and process for the preparation thereof

A method of preparing a sustained release tablet, the method comprising:

• providing granules comprising a pharmaceutically active ingredient and a water-insoluble polymer;
• coating the granules with a sustained release base material so as to form sustained release pellets;
• providing rapid release granules comprising the pharmaceutically active ingredient;
• mixing the sustained release pellets and rapid release granules together with pharmaceutically acceptable additives so as to provide a mixture;
• and
• shaping the mixture into a tablet.

A method of preparing a sustained release capsule, the method comprising:

• providing granules comprising a pharmaceutically active ingredient and a water-insoluble polymer;
• coating the granules with a sustained release base material so as to form sustained release pellets;
• providing rapid release granules comprising the pharmaceutically active ingredient;
• and
• filling the sustained release pellets and rapid release granules into a capsule.