Methods For the Preparation of Stable Pharmaceutical Solid Dosage Forms of Atorvastatin and Amlodipine
AssigneeRanbaxy Laboratories Limited
InventorsShrikant S. Chaudhari, Romi Barat Singh, Vishnubhotla Nagaprasad
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Abstract
The present invention relates to pharmaceutical compositions comprising amlodipine and pharmaceutically acceptable salts thereof, and atorvastatin and pharmaceutically acceptable salts thereof, and processes for their preparation.
Claims13
A process for making a pharmaceutical composition comprising amlodipine and atorvastatin or pharmaceutically acceptable salts thereof, the process comprising:
- a) blending atorvastatin and one or more pharmaceutically inert excipients;
- b) blending amlodipine and one or more pharmaceutically inert excipients;
- c) mixing the blends;
- d) optionally granulating the blend;
- e) lubricating the blend of step c) or granules of step d);
- and
- f) filling the blend/granules into a capsule or compressing into tablet.
-7. (canceled)
A process for making a pharmaceutical composition comprising amlodipine and atorvastatin or pharmaceutically acceptable salts thereof, the process comprising:
- a) preparing atorvastatin granules/blend by
- i) blending atorvastatin and one or more pharmaceutically inert excipients,
- ii) optionally granulating the blend,
- iii) lubricating the granules/blend;
- and
- b) preparation of amlodipine granules/blend by
- i) blending amlodipine and one or more pharmaceutically inert excipients,
- ii) optionally granulating the blend,
- iii) lubricating the granules/blend.
-15. (canceled)
-20. (canceled)
Dependencies are inferred from the claim text.