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AssigneeMylan Technologies, Inc.
InventorsKristin Jackson, Kenneth James Miller, II
Estimating the term…
A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
The transdermal drug-containing dosage unit of claim 37, wherein said drug comprises a cardiovascular drug, an androgenic steroid, an estrogen, a progestational agent, a drug which acts on the central nervous system, a nutritional agent, an anti-inflammatory agent, an antihistamine, a miotic, a dermatological agent, an anti-spasmodic, an anti-depressant, an anti-cancer drug, an anti-diabetic, an anti-estrogen, an anti-psychotic, an anti-infective agent, an anti-allergenic, an anti-pyretic, an anti-migraine agent or a tranquilizer.
The transdermal drug-containing dosage unit of claim 37, wherein said drug comprises an estrogen or a combination of an estrogen and a progestin.
The transdermal drug-containing dosage unit of claim 37 which comprises from about 0.05% to about 40% w/w of drug.
A method for administering a drug transdermally to an individual in need of such administration, comprising applying to skin of the individual a transdermal dosage unit comprising:
A transdermal delivery device for the transdermal delivery of an active substance, for example a pharmacologically active substance, the device having first and second superimposed mutually contacting adhesive layers, of which said first layer is pressure sensitive adhesive and is in use brought into contact with the skin, the active substance being dissolved in both said layers, wherein the affinity of said first layer for said active substance is between about 1.15 and about 10 times lower than that of said second layer, the percent saturation of said active substance in both said layers being the same and being less than 100%, said first layer having a greater thickness than said second layer.
A transdermal delivery device for the transdermal delivery of an active substance, for example a pharmacologically active substance, the device having first and second superimposed mutually contacting adhesive layers, of which said first layer is pressure sensitive adhesive and is in use brought into contact with the skin, the active substance being dissolved in both said layers, wherein the affinity of said first layer for said active substance is between about 1.15 and about 10 times lower than that of said second layer, the percent saturation of said active substance in both said layers being the same and being less than 100%.
A transdermal delivery device for the transdermal delivery of an active substance, for example a pharmacologically active substance, the device having first and second superimposed mutually contacting adhesive layers, of which said first layer is pressure sensitive adhesive and is in use brought into contact with the skin, the active substance being dissolved in both said layers, wherein the difference in drug delivery rate of said active substance in said first layer is between about 10% and about 100% higher than that of said active substance in said second layer, the percent saturation of said active substance in both said layers being the same and being less than 100%.
A transdermal drug-containing dosage unit which comprises a laminate comprising:
A transdermal drug-containing dosage unit which comprises a laminate comprising:
A method for preparing a transdermal drug-containing dosage unit comprising a laminate consisting of a backing layer, a first polymeric adhesive matrix, a second polymeric adhesive matrix, a third middle polymeric adhesive matrix, and a release liner, said method comprising the steps of:
A method for preparing a transdermal drug-containing dosage unit comprising a laminate consisting of a backing layer, a first polymeric adhesive matrix, a second polymeric adhesive matrix and a release liner, said method comprising the steps of:
A method for administering a drug transdermally to an individual in need of such administration, comprising applying to skin of the individual a transdermal dosage unit comprising a laminate comprising:
Dependencies are inferred from the claim text.