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US 2008/0305141 A1Published application
Freeze-thaw method for modifying stent coating
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsSyed F. A. Hossainy, Gordon Stewart, Benjamyn Serna, Lothar W. Kleiner
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Abstract
Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
Claims20
A method comprising:
- (a) preparing a coating composition comprising one or more polymers, one or more solvents and optionally one or more therapeutic agents;
- (b) applying the coating composition onto a medical device to form a wet coating layer;
- and
- (c) subjecting the wet coating layer to a freeze-thaw cycle.
1 more element
A method comprising:
- (a) preparing a coating composition comprising one or more polymers, one or more solvents, and optionally one or more active agents;
- (b) applying the coating composition onto a medical device to form a wet coating layer;
- (c) removing the solvent(s) to form a dry coating layer, the dry coating layer having less than 2% solvent(s);
- and
- (d) subjecting the dry coating layer to a freeze-thaw cycle.
2 more elements
Dependencies are inferred from the claim text.