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OwnerBerislav V. Zlokovic, Dong Liu +2inventors
InventorsBerislav V. Zlokovic, Dong Liu, Tong Cheng, Huang Guo
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Activated protein C (APC), a prodrug, and/or a variant of APC may be used to inhibit undesirable effects of plasminogen activator: e.g., apoptosis or cell death of neurons and endothelial cells, brain hemorrhage or intracerebral bleeding, and/or tissue damage in a subject's brain. Inhibition appears to act through the extrinsic pathway of death receptor signal transduction. This represents an improvement in treatment using plasminogen activator (e.g., fibrinolysis). By reducing undesirable effects, the window for fibrinolytic therapy by plasminogen activator may be widened.
A method of inhibiting deleterious effects of plasminogen activator in a subject's brain, said method comprising:
(canceled)
A process of screening for an agent, said process comprising:
A process of screening for an agent, said process comprising:
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