1,4-Bis-N-Oxide-5,8- Dihydroxyanthracenedione Compounds and the Use Thereof

A compound having Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 and R2 are independently hydrogen, halo, alkyl, carboxyl, carboxylester, carboxylamide, thioalkyl, hydroxy, alkoxy, aryloxy, sulfonyl, sulfonic acid, or polyethylene glycol, or R1 and R2 together form an aryl group;
• R3 and R4 independently are hydrogen or fluorine, or R3 and R4 together form an aryl group;
• R5 and R6 independently are hydrogen, alkyl, or hydroxyalkyl;
• or R1 and R5 together, and/or R2 and R6 together, form a ring;
• R7 and R9 are independently alkyl, hydroxyalkyl, haloalkyl, or with the neighboring nitrogen form a heterocycle;
• R9 and R10 are independently alkyl, hydroxyalkyl, haloalkyl, or together with the neighboring nitrogen form a heterocycle;
• A and B independently are (CH2)n, cycloalkyl, or aryl, or with the two neighboring nitrogens forms a heterocycle;
• and
• n is 1, 2, 3, or 4;
• with the proviso that at least one of R1, R2, R3, R4, R5 and R6 is other than hydrogen;
• or
• at least one of R7, R8, R9, and R10 is haloalkyl;
• or R7 and R8, and/or R9 and R10, form a heterocycle with the neighboring nitrogen;
• or
• at least one of A and B is cycloalkyl, heterocyclic or aryl or forms a heterocycle with the two neighboring nitrogens.