Therapeutic Agents for the Treatment of Hmgb1-Related Pathologies
OwnerDomenico G. Barone, Marco E. Bianchi +5inventors
InventorsDomenico G. Barone, Marco E. Bianchi, Enrico M. Bucci, Silvano Fumero, Margherita Valente, Roberto Sapio, Domenica Musumeci
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Abstract
The present invention relates to the use of synthetic double-stranded nucleic acid or nucleic acid analogue molecules with a bent shape structure for the prevention and treatment of pathologies induced directly or indirectly by the HMGB1 protein.
Claims37
Use of synthetic double-stranded nucleic acid or nucleic acid analogue molecules with a bent shape structure, capable of binding to the HMGB1 protein or to HMGB1 homologous proteins for the manufacture of a medicament for the prevention or treatment of HMGB1-associated pathologies or pathologies associated with HMGB1 homologous proteins.
Kit of claim 37, wherein the non-acetylated or/and the acetylated form of HMGB1 or/and of HMGB1 homologous proteins is determined.
Dependencies are inferred from the claim text.