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US 2008/0305037 A1Published application
Linkers for anchoring targeting ligands
AssigneeKereos, Inc.
InventorWilliam D. McGhee
Life of this patent
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Abstract
An improved linker which lacks chiral centers between a hydrophobic anchor for coupling to lipid-based particles and a targeting agent has suitable hydrophobic/hydrophilic properties for use in vivo.
Claims13
A compound of the formula
- targeting agent-SO2-phenylene-O(CH2)nCONH(CH2)nNHCO(CH2)n—CONH(CH2)nO(CH2CH2O)xCH2CH2OCZ-anchor (1)
- wherein each n is independently 1-4;
- x is an integer of 20-60;
- Z is =NH or =O;
- the targeting agent is a moiety containing an amino group or a hydroxyl group for coupling to the remainder of the molecule;
- and
- the anchor is a lipophilic compound for embedding the compound in a lipid based particulate.
4 more elements
Dependencies are inferred from the claim text.