Back to results
US 2008/0300798 A1Published application
Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics
OwnerJohn T. McDevitt, Nicolaos Christodoulides +3inventors
InventorsJohn T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, Craig S. Miller, Jeffrey L. Ebersole
Life of this patent
Estimating the term…
Abstract
Embodiments of the invention include methods by which cardiac biomarkers are assigned an index (cardiovascular biomarker index-cardiobioindex, CBI) as a means to describe the utility of each biomarker, or combination of biomarkers for risk evaluation, diagnosis or prognosis of cardiovascular disease status.
Claims17
A method for assessing cardiovascular disease status in a subject comprising the steps of:
- (a) measuring a biomarker level in a sample from a subject, wherein the biomarker is two or more of CRP, IL1β, IL-13, cTnI, BNP, FABP, CK-MB, IL-6, IL-8, IL-10, TNF-α, CD40L, IFN-γ, myoglobin, MMP9, sICAM-1, myeloperoxidase, IL-4, and/or IL-5;
- (b) evaluating biomarker levels with respect to a scoring index, wherein evaluation comprises:
- (i) assigning an index to each biomarker or combination of biomarkers based on its/their measured capacity to discriminate between cardiac healthy subjects and cardiac disease patients,
- (ii) establishing a threshold level of the biomarker with an index greater than 0.8 to discriminate cardiac healthy subjects from cardiac disease patients;
- and
- (c) determining a value representative of the cardiovascular disease status of the subject based on the evaluation of subject's biomarker.
3 more elements
A method of establishing a cardiobioindex comprising the steps of:
- (a) obtaining a plurality of samples from a first and second population of subjects, wherein the first population has a normal cardiac status and the second population has a cardiovascular condition;
- (b) quantifying the level of a factor in each sample;
- (c) comparing the factor levels between the healthy subjects and the cardiac patients;
- (d) determining the cardiobioindex of the factor by logistic regression and ROC analyses;
- and
- (e) utilizing factors with cardiobioindex greater than 0.8 for cardiac diagnostics.
3 more elements
Dependencies are inferred from the claim text.