Human Polyclonal Antibodies from Genetically Engineered Animals
OwnerJens-Ulrich Buelowinventor
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Abstract
Substantially human antisera are provided by genetically modifying a domestic animal generally weighing at least about 1 kg. The domestic animal is genetically modified by generating inactive heavy and light chain immunoglobulin loci and integrating at least functional portions of the human heavy and light chain immunoglobulin loci, whereby the human loci generate an immune response. The antisera find use in the treatment of diseases, immunocompromised patients and in case of transplantation.
Claims16
A polyclonal antisera composition of a transgenic rabbit, wherein said antisera composition is comprised predominantly of a population of polyclonal immunoglobulin protein molecules comprising at least a portion of a human immunoglobulin heavy chain constant region, and variable region amino acid sequences encoded by fragments of more than one variable (V) region gene, wherein said immunoglobulin protein molecules specifically recognize and bind to an immunogen.
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