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US 2008/0293790 A1Published application
Substituted aryl oximes
AssigneeWyeth
InventorsLisa Marie Havran, John Anthony Butera, Hassan Mahmoud Elokdah, Douglas John Jenkins, Eric Gould Gundersen
Life of this patent
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Abstract
The present invention relates to substituted aryl oximes and methods of using them.
Claims24
A compound of the formula:
- or a pharmaceutically acceptable salt or ester form thereof
- wherein:
- R1 is a direct bond to A, C1-C4 alkylene, or —O—C1-C4 alkylene;
- R2 and R3 are, independently hydrogen, halogen, C1-C4 alkyl, C1-C3 perfluoroalkyl, —O—C1-C3 perfluoroalkyl, C1-C3 alkoxy, —OH, —NH2, —NO2, —O(CH2)p-aryl, —O(CH2)p-heteroaryl, aryl, heteroaryl, —NH(CH2)p-aryl, —NH(CH2)p-heteroaryl, —NH(CO)-aryl, —NH(CO)-heteroaryl, —O(CO)-aryl, —O(CO)-heteroaryl, —NH(CO)—CH═CH-aryl, or —NH(CO)—CH═CH-heteroaryl;
- p is an integer from 0-6;
- R4 is hydrogen, C1-C8 alkyl, or C3-C6 cycloalkyl;
- A is COOH or an acid mimic;
- X is C1-C8 alkylene, C3-C6 cycloalkylene, —(CH2)mO—, or —(CH2)mNH—;
- m is an integer from 1-6;
- R5 and R6, are, independently, hydrogen, halogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, —O—C1-C6 perfluoroalkyl, C1-C6 alkoxy, —OH, —NH2, —NO2, —O(CH2)n-aryl, —O(CH2)n-heteroaryl, aryl, or heteroaryl;
- and
- n is an integer from 0-6,
- wherein C1-C4 alkylene, —O—C1-C4alkylene, alkyl, aryl and heteroaryl are each optionally substituted by one or more substituents.
10 more elements
9-10. (canceled)
12-18. (canceled)
A method for treating thrombosis, atrial fibrillation, pulmonary fibrosis, thromboembolic complication of surgery, stroke, myocardial ischemia, atherosclerotic plaque formation, chronic obstructive pulmonary disease, or renal fibrosis comprising administering to a subject in need thereof a therapeutically effective amount of the compound of formula:
- or a pharmaceutically acceptable salt or ester form thereof
- wherein:
- R1 is a direct bond to A, C1-C4 alkylene, or —O—C1-C4 alkylene;
- R2 and R3 are, independently hydrogen, halogen, C1-C4 alkyl, C1-C3 perfluoroalkyl, —O—C1-C3 perfluoroalkyl, C1-C3 alkoxy, —OH, —NH2, —NO2, —O(CH2)p-aryl, —O(CH2)p-heteroaryl, aryl, heteroaryl, —NH(CH2)p-aryl, —NH(CH2)p-heteroaryl, —NH(CO)-aryl, —NH(CO)-heteroaryl, —O(CO)-aryl, —O(CO)-heteroaryl, —NH(CO)—CH═CH-aryl, or —NH(CO)—CH═CH-heteroaryl;
- p is an integer from 0-6;
- R4 is hydrogen, C1-C8 alkyl, or C3-C6 cycloalkyl;
- A is COOH or an acid mimic;
- X is C1-C8, alkylene, C3-C6 cycloalkylene, —(CH2)mO—, or —(CH2)mNH—;
- m is an integer from 1-6;
- R5 and R6, are, independently, hydrogen, halogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, —O—C1-C6 perfluoroalkyl, C1-C6 alkoxy, —OH, —NH2, —NO2, —O(CH2)n-aryl, —O(CH2)n-heteroaryl, aryl, or heteroaryl;
- and
- n is an integer from 0-6.
9 more elements
A compound of the formula:
- or a pharmaceutically acceptable salt or ester form thereof
- wherein:
- R1 is a direct bond to A, C1-C4 alkylene, or —O—C1-C4 alkylene;
- R2 and R3 are, independently hydrogen, halogen, C1-C4 alkyl, C1-C3 perfluoroalkyl, —O—C1-C3 perfluoroalkyl, C1-C3 alkoxy, —OH, —NH2, —NO2, —O(CH2)p-aryl, —O(CH2)p-heteroaryl, aryl, heteroaryl, —NH(CH2)p-aryl, —NH(CH2)p-heteroaryl, —NH(CO)-aryl, —NH(CO)-heteroaryl, —O(CO)-aryl, —O(CO)-heteroaryl, —NH(CO)—CH═CH-aryl, or —NH(CO)—CH═CH-heteroaryl;
- p is an integer from 0-6;
- R4 is hydrogen, C1-C8 alkyl, or C3-C6 cycloalkyl;
- A is COOH or an acid mimic;
- X is C1-C8 alkylene, C3-C6 cycloalkylene, —(CH2)mO—, or —(CH2)mNH—;
- m is an integer from 1-6;
- R5 and R6, are, independently, hydrogen, halogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, —O—C1-C6 perfluoroalkyl, C1-C6 alkoxy, —OH, —NH2, —NO2, —O(CH2)n-aryl, —O(CH2)n-heteroaryl, aryl, or heteroaryl;
- and
- n is an integer from 0-6
9 more elements
Dependencies are inferred from the claim text.