Bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, processes for their preparation, pharmaceutical compositions and methods for their use

A compound of formula I:

• wherein
• R1 is selected from the group consisting of (C1-C6)alkyl, (C0-C6)alkylene (C3-C6)cycloalkyl, (C0-C6)alkylene-O—(C1-C6)alkyl, (C0-C6)alkylene-O—(C3-C6)cycloalkyl and (C0-C6)alkylene-(C6-C14)aryl and (C0-C6)alkylene-(C5-C15)heteroaryl, wherein alkyl, alkylene, aryl, heteroaryl and cycloalkyl can be unsubstituted or mono, di- or tri substituted by F, Cl, Br, OCF3, CN, CO—(C1-C6)alkyl, COO(C1-C6)alkyl, CON((C0-C6)alkylene-H)((C0-C6)alkylene-H), S(O)m (C1-C6)alkyl;
• R2, R3, R4 and R5 are independently selected from the group consisting of H, halogen, (C1-C6)alkyl, (C0-C4)alkylene-O—(C0-C4)alkylene-H, CN, COO(C1-C6)alkyl, CON((C0-C6)alkylene-H)((C0-C6)alkylene-H) and S(O)m(C1-C6)alkyl, wherein alkyl and alkylene are unsubstituted or mono, di- or trisubstituted by F;
• A is selected from the group consisting of (C6-C14)aryl and (C4-C10) heteroaryl;
• n is 1, 2, 3;
• m and z are 0, 1, 2;
• R6, R7 and R8 are independently selected from the group consisting of H, (C1-C6)alkyl, CN, CO—(C1-C6)alkyl, COO—(C1-C6)alkyl, CON((C0-C6)alkylene-H((C0-C6)alkylene-H), S(O)m(C1-C6)alkyl, N((C0-C6)alkylene-H)((C0-C6)alkylene-H), N((C0-C6)alkylene-H)—CO—(C1-C6)alkyl, N((C0-C6)alkylene-H)—CO—(C1-C6)alkyl, halogen, (C0-C6)alkylene-O—(C0-C6)alkylene-H, (C0-C6)alkylene-O—(C6-C14)aryl, SCF3, S(O)2CF3 and NO2, wherein alkyl, aryl and alkylene are unsubstituted or mono, di- or trisubstituted by F;
• its' stereoisomers, enantiomers, tautomers, physiologically acceptable salts and mixtures thereof.