Stevioside Polymorphic and Amorphous Forms, Methods for Their Formulation, and Uses
AssigneeThe Coca-Cola Company
InventorsIndra Prakash, Mani Upreti
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Abstract
Exemplary embodiments of this invention encompass a method for purifying a substantially crude stevioside, methods for preparing polymorphic and amorphous forms of stevioside, and the polymorphic and amorphous forms prepared therefrom.
Claims39
A method for purifying stevioside comprising the steps of:
- combining crude stevioside and an organic solvent or an aqueous organic solvent to form a stevioside solution, the aqueous organic solution comprising water in an amount from about 5% to about 25% by weight;
- and
- crystallizing from the stevioside solution in a single step a substantially pure stevioside composition comprising stevioside in a purity greater than about 95% by weight on a dry basis.
A substantially pure stevioside composition comprising a polymorph having an X-ray diffraction pattern substantially similar to FIG. 2.
A substantially pure stevioside composition comprising a polymorph having an X-ray diffraction pattern substantially similar to FIG. 3.
A substantially pure stevioside composition comprising a polymorph having an X-ray diffraction pattern substantially similar to FIG. 4.
A substantially pure stevioside composition comprising an amorphous form having an X-ray diffraction pattern substantially similar to FIG. 5.
A composition comprising a combination of stevioside polymorphic and/or amorphous forms, the combination comprising a plurality of stevioside polymorphic and/or amorphous forms selected from the group consisting of a polymorph having an X-ray diffraction pattern substantially similar to FIG. 2, a polymorph having an X-ray diffraction pattern substantially similar to FIG. 3, a polymorph having an X-ray diffraction pattern substantially similar to FIG. 4, and an amorphous form having an X-ray diffraction pattern substantially similar to FIG. 5.
Dependencies are inferred from the claim text.