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US 2008/0287693 A1Published application
Process for the Preparation of 1-Naphthol Mixed Ethers and Intermediates of Crystalline Forms of (+) and (-)-Duloxetine
AssigneeSolmag S.p.A.
InventorsSamuele Frigoli, Claudio Fuganti, Roberta Pizzocaro
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Abstract
The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol in the presence of 1,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed.
Claims1
A process for the preparation of duloxetine 1a:
- comprising the reaction between 1-fluoronaphthalene 3b
- and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol 2a
- to give ((+)-(S)—N,N-dimethyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine) 1b:
- and the conversion of 1b to duloxetine 1a,
- characterized in that the reaction between 2a and 3b is carried out in 1,3-dimethyl-2-oxo-hexahydropyrimidine as the solvent.
2 more elements
Dependencies are inferred from the claim text.