Cefdinir process

Abstract

The present invention provides an improved process for the preparation of high assayed cefdinir. Thus, crude cefdinir is added to water at 25-30° C. and then 18% hydrochloric acid is slowly added to form a clear solution. The solution is cooled to −5° C. and stirred for 5 minutes at −5° C. to +5° C. Then temperature of the mass is raised to 35-38° C., stirred for 15 minutes at the same temperature. To the reaction mass eno carbon is added at 35-38° C. and stirred for 30 minutes at 35-38° C. Then the contents are filtered on hiflo bed and washed with water. The filtrate is then cooled to 25° C., the pH is slowly adjusted to 2.6 with saturated sodium bicarbonate solution and stirred for 60 minutes at 25-30° C. Filtered the solid, washed with water and dried at 40° C. under vacuum to give high assayed cefdinir.

Dependencies are inferred from the claim text.