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US 2008/0287628 A1Published application
Endosomolytic Poly(Vinyl Ether) Polymers
AssigneeRoche Madison Inc.
InventorsDavid B. Rozema, Darren H. Wakefield, Sean D. Monahan, Lori Higgs, Jon A. Wolff, James E. Hagstrom
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Abstract
The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
Claims19
A membrane active random poly(vinyl ether) comprising:
- a plurality of amine-containing monomers, a plurality of first hydrophobic monomers, and a plurality of second hydrophobic monomers wherein said first and second hydrophobic monomers are different.
A reversibly masked membrane active random poly(vinyl ether) comprising:
- a plurality of amine-containing monomers, a plurality of first hydrophobic monomers, and a plurality of second hydrophobic monomers wherein said first and second hydrophobic monomers are different and wherein one or more amines of the amine-containing monomers are linked to masking agents via physiologically labile bonds thereby inhibiting membrane activity of the membrane active random poly(vinyl ether).
Dependencies are inferred from the claim text.