Pyridinone Derivatives Against Malaria

A compound represented by the following Formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• Het represents a 6-membered monocyclic heteroaromatic ring containing at least one nitrogen atom, wherein Het is substituted through a carbon atom with one group Z, wherein Z represents:
• i) a phenyl or methylenedioxyphenyl group, either of which is optionally substituted with one or more RX groups;
• ii) a —OC1-6alkylphenyl group, wherein the phenyl portion is optionally substituted with one or more RX groups;
• iii) a C1-10alkyl, a-Oaryl, a-C1-6alkylaryl, a-C2-6alkenylaryl or a-C2-6alkynylaryl group, wherein any aryl portion is optionally substituted with one or more RX group;
• RX represents halogen, cyano, —NRARA, C1-6alkyl, C1-6alkoxy or C1-6alkylS(O)m—;
• m represents 0-2;
• R1 represents halogen, hydrogen, or cyano;
• R2 represents hydrogen, hydroxy, —C(O)RY, —C(O)OH or C1-6alkyl optionally substituted by halogen, hydroxy, —C(O)OH, —C(O)RY or —NRARB;
• RA and RB independently represent hydrogen or C1-6alkyl;
• RY represents C1-6alkoxy or C1-6alkyl;
• and
• R3 and R4 are independently C1-6alkyl.