Methods for preparing eszopiclone
OwnerNina Finkelstein, Marioara Mendelovici +2inventors
InventorsNina Finkelstein, Marioara Mendelovici, Revital Ramaty, Alex Mainfeld
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Abstract
Methods for the preparation of crystalline eszopiclone free base in water, in the absence of organic solvents, are provided. The methods are more environmentally acceptable than prior art methods, and produce eszopiclone free base essentially free of residual organic solvent.
Claims31
Eszopiclone having less than about 5000 ppm residual organic solvent.
A process for preparing eszopiclone comprising reacting a salt of eszopiclone with a base in one phase reaction mixture comprising water to obtain eszopiclone.
A process for improving the color of eszopiclone by an activated carbon treatment comprising dissolving a salt of D-(+)-eszopiclone in water;
- and adding activated carbon.
Dependencies are inferred from the claim text.