Novel Solubility Enhancer and Use Thereof
OwnerRamachandran Radhakrishnaninventor
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Abstract
Disclosed herein is a novel solubility enhancer capable of being employed in formulating safe and effective pharmaceutical formulations of partially soluble drugs, wherein the solubility enhancer is selected from dialkyl substituted amides of fatty acids having C6 to C16 carbon chain, preferably from N,N-dimethyl hexanamide, N,N-dimethyl octanamide, N,N-dialkyl decanamide, N,N-dialkyl dodecanamide or N,N-dialkyl hexadecanamide.
Claims22
A novel solubility enhancer for solubilising partially soluble drugs, wherein said solubility enhancer is N,N-dialkylamide of aliphatic carboxylic acids having C6 to C16 carbon chain.
A method for enhancing the solubility of partially soluble drugs, wherein the method comprises mixing said drugs into a hydrophilic medium, adding a solubility enhancer into resultant mixture, shaking the resultant to obtain clear solution, wherein said solubility enhancer is N,N-dialkylamide of aliphatic carboxylic acids having C6 to C16 carbon chain.
A method for preparing a pharmaceutical formulation, wherein the method comprises mixing partially soluble drugs into a hydrophilic medium, adding a solubility enhancer into resultant mixture, shaking the resultant to obtain clear solution, and formulating the same using pharmaceutically acceptable excipients into a desirable drug delivery system, wherein said solubility enhancer is N,N-dialkylamide of aliphatic carboxylic acids having C6 to C16 carbon chain.
Dependencies are inferred from the claim text.