Thiadiazole compounds and methods of use

A compound of Formula I

• wherein:
• Y is —N(R4)R5 or —OR5;
• X is O, S, or N(R6);
• R1 is an aryl or heteroaryl;
• R2 and R3 together with the carbon atom to which they are attached join to form a C3-C10 heterocyclic or carbocyclic ring system;
• R4 is —H, C1-C8 alkyl, —C(O)(CR7R8)t)N(R6)2, —C(O)(CR7R8)t, —C(O)2(CR7R8)t, —(CR7R8)t(aryl), —(CR7R8)t(heteroaryl), —(CR7R8)t(cycloalkyl), or —(CR7R8)t(heterocyclyl);
• R5 and R6 are independently selected from —H and C1-C8 alkyl, or R5 and R6 together with the atoms to which they are linked join to form a 5 to 6-membered heterocyclic ring, or
• R4 and R5 together with the nitrogen atom to which they are linked join to form a 5 to 6-membered heterocylic or heteroaryl ring;
• and
• R7 and R8 are independently selected from —H, C1-C6 alkyl, and aryl;
• wherein n is 1;
• m is an integer from 0 to 2;
• and each t is independently an integer from 0 to 3;
• wherein each of the above alkyl, aryl, heteroaryl, cycloalkyl, heterocyclyl moieties and heterocyclic and carbocyclic rings are optionally and independently substituted by 1-3 substituents selected from
• amino,
• aryl, heteroaryl, cycloalkyl, or heterocyclyl optionally substituted by 1-5 substituents selected from
• C1-C6 alkoxy,
• C1-C6 alkyl optionally substituted by halo,
• aryl,
• halo,
• heteroaryl,
• C1-C6 hydroxyl, and
• —NHS(O)2—C6 alkyl);
• C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 alkylamino,
• C2-C6 alkenyl, or C2-C6 alkynyl, wherein each of which may be interrupted by one or more hetero atoms,
• cyano,
• halo,
• hydroxy,
• nitro, or
• —O-aryl;
• or a pharmaceutically acceptable salt, hydrate, or stereoisomer thereof.