Genetically engineered and phenotyped mice and stem cell clones for producing the same

A transgenic mouse whose genome comprises a disruption of a gene and wherein said disruption results in a phenotype that differs form the phenotype of a wild-type mouse, said gene selected from the group consisting of:

• a. a gene comprising SEQ ID NO:9, wherein the disruption of the gene comprising SEQ ID NO:9 results in decreased depressive-like response in (−/−) mice;
• b. a gene comprising SEQ ID NO:10, wherein the disruption of the gene comprising SEQ ID NO:10 results increased artery-to-vein ratios in (−/−) mice;
• c. a gene comprising SEQ ID NO:11, wherein the disruption of the gene comprising SEQ ID NO:11 results in infertile female (−/−) mice exhibiting ovarian hypoplasia;
• d. a gene comprising SEQ ID NO:12, wherein the disruption of the gene comprising SEQ ID NO:12 results in an increased percentage of natural killer cells in (−/−) mice;
• e. a gene comprising SEQ ID NO:14, wherein the disruption of the gene comprising SEQ ID NO:14 results in a decreased percentage of CD8 cells and an increased percentage of B cells in the peripheral blood of (−/−) mice;
• f. a gene comprising SEQ ID NO:15, wherein the disruption of the gene comprising SEQ ID NO:15 results in compensated hemolytic anemia in (−/−) mice;
• g. a gene comprising SEQ ID NO:16, wherein the disruption of the gene comprising SEQ ID NO:16 results in decreased bone mineral content and density in (−/−) mice;
• h. a gene comprising SEQ ID NO:17, wherein the disruption of the gene comprising SEQ ID NO:17 results in decreased red blood cell count in (−/−) mice;
• i. a gene comprising SEQ ID NO:18, wherein the disruption of the gene comprising SEQ ID NO:18 results in an increased percentage of NK cells in (−/−) mice;
• j. a gene comprising SEQ ID NO:19, wherein the disruption of the gene comprising SEQ ID NO:19 results in increased serum IgG1 and IgG2a responses to ovalbumin challenge in (−/−) mice;
• k. a gene comprising SEQ ID NO:20, wherein the disruption of the gene comprising SEQ ID NO:20 results in enhanced learning/memory in male (−/−) mice;
• l. a gene comprising SEQ ID NO:21, wherein the disruption of the gene comprising SEQ ID NO:21 results in small male (−/−) mice, exhibiting a decreased fasting serum glucose level;
• m. a gene comprising SEQ ID NO:22, wherein the disruption of the gene comprising SEQ ID NO:22 results in impaired sensorimotor gating/attention in (−/−) mice;
• n. a gene comprising SEQ ID NO:23, wherein the disruption of the gene comprising SEQ ID NO:23 results in immunological abnormalities in (−/−) mice;
• o. a gene comprising SEQ ID NO:24, wherein the disruption of the gene comprising SEQ ID NO:24 results in decreased pain response in (−/−) mice;
• and
• p. a gene comprising SEQ ID NO:25, wherein the disruption of the gene comprising SEQ ID NO:25 results in increased serum glucose levels in (+/−) and (−/−) animals.