Osteoinductive bone material

A formable, self-hardening, poorly crystalline apatitic (PCA) calcium phosphate paste suitable for use as a bone implant material comprising:

• (a) a powder component comprising:
• (i) demineralized bone matrix (DBM) particles,
• (ii) a calcium phosphate powder;
• and
• (b) a physiologically-acceptable fluid in an amount to produce a cohesive, formable paste, wherein said paste retains its cohesiveness when introduced at an implant site in vivo and hardens to form a PCA calcium phosphate having a compressive strength of greater than at least about 1 MPa.

A formable, self-hardening, poorly crystalline apatitic (PCA) calcium phosphate paste suitable for use as a bone implant material comprising:

• (a) a powder component, including:
• (i) demineralized bone matrix (DBM) particles,
• (ii) a calcium phosphate powder, and
• (iii) a biocompatible cohesiveness agent;
• and
• (b) a physiologically acceptable fluid in an amount to produce a cohesive, formable paste, wherein said paste retains its cohesiveness when introduced at an implant site in vivo and hardens to form a PCA calcium phosphate having a compressive strength of greater than at least about 1 MPa.

A formable, self-hardening, poorly crystalline apatitic (PCA) calcium phosphate paste suitable for use as a bone implant material comprising:

• (a) a powder component, including:
• (i) demineralized bone matrix (DBM) particles, wherein said demineralized bone matrix particles are present in an amount between about 1 wt % and about 50 wt % of said powder component, and
• (ii) a calcium phosphate powder comprised of an amorphous calcium phosphate and a second calcium phosphate source, wherein said amorphous calcium phosphate and said second calcium phosphate source have an average crystalline domain size of less than about 100 nm and wherein said calcium phosphate powder is present in an amount between about 50 wt % and about 99 wt % of said powder component, and
• (b) a physiologically acceptable fluid in an amount to produce a coherent, formable paste, wherein said paste retains its cohesiveness when introduced at an implant site in vivo and hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having a compressive strength between about 1 MPa and about 20 MPa.

A formable, self-hardening, poorly crystalline apatitic (PCA) calcium phosphate paste suitable for use as a bone implant material comprising:

• (a) a powder component, including:
• (i) demineralized bone matrix (DBM) particles, wherein said demineralized bone matrix particles are present in an amount between about 1 wt % and about 50 wt % of said powder component,
• (ii) a calcium phosphate powder comprised of an amorphous calcium phosphate and a second calcium phosphate source, wherein said amorphous calcium phosphate and said second calcium phosphate source have an average crystalline domain size of less than about 100 nm and wherein said calcium phosphate powder is present in an amount between about 50 wt % and about 99 wt % of said powder component, and
• (iii) a biocompatible cohesiveness agent, wherein said cohesiveness agent is present in an amount between about 1 wt % and about 20 wt % of said powder component;
• and
• (b) a physiologically-acceptable fluid in an amount to produce a coherent, formable paste, wherein said paste retains its cohesiveness when introduced at an implant site in vivo and hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having a compressive strength between 1 MPa and 20 MPa.

A bone implant material comprising a poorly crystalline apatitic (PCA) calcium phosphate, wherein said PCA calcium phosphate is formed by combining:

• (a) a powder component, including:
• (i) demineralized bone matrix (DBM) particles,
• (ii) a calcium phosphate powder comprised of an amorphous calcium phosphate and a second calcium phosphate source, wherein said second calcium phosphate source is an acidic calcium phosphate, and
• (iii) a biocompatible cohesiveness agent;
• and
• (b) a physiologically-acceptable fluid,
• wherein said powder component and said liquid combine to produce a paste that hardens to form a PCA calcium phosphate having a compressive strength between about 1 MPa and about 20 MPa.