US 2008/0188927 A1 · ENDOVASCULAR IMPLANT WITH ACTIVE COATING

Abstract

The invention concerns an endovascular implant, in particular a stent, with an at least portion-wise active coating. The object of the present invention is to provide locally therapeutic formulations for the treatment of stenosis or restenosis. The implants modified in accordance with the invention are to ensure improved compatibility, in particular in regard to any inflammatory and proliferative processes in the tissue environment. That is achieved in that the active coating includes, as an active substance: 1) PPARα-agonists, PPARδ-agonists or a combination thereof; 2) an RXR-agonist; or 3) a combination of PPAR-agonists and RXR-agonists.

Claims20

Dependent claims

An endovascular implant, comprising:

an active coating comprising a combination of PPARδ-agonists and RXR-agonists as an active substance on at least a portion of the endovascular implant.

Dependencies are inferred from the claim text.

Facts

Application

11/951,620Filed 6 Dec 2007

Priority

DE 102 37 571.213 Aug 2002

Published

7 Aug 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61L 31/16
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…
A61F 2/91
Characterised by a net-like or mesh-like structure: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
A61L 2300/416
Characterised by a specific therapeutic activity or mode of action: anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic…
A61L 2300/45
Characterised by a specific therapeutic activity or mode of action: mixtures of two or more drugs, e.g. synergistic mixtures

Endovascular implant with active coating

Life of this patent

Endovascular implant with active coating

Life of this patent

Abstract

Claims20