Ecg-based identification of impaired ikr kinetics

A system for assaying impaired delayed rectifier potassium current function, comprising:

• a processor configured to determine an indication of impaired delayed rectifier potassium current function based on a comparison of T-wave amplitudes from ECG data with corresponding heart rates for the T-wave amplitudes;
• a data input coupled to the processor and configured to provide the processor with the ECG data;
• and
• a user interface coupled to either the processor or the data input.

A method for determining the ability of a pharmacological agent to impair delayed rectifier potassium current function, comprising:

• obtaining a baseline electrocardiogram (ECG) for a mammal at different heart rates;
• determining a baseline dependency of a plurality of T-wave amplitudes on corresponding heart rates for the baseline ECG;
• administering the pharmacological agent to the mammal;
• obtaining a follow-on ECG for the mammal at different heart rates;
• determining a follow-on dependency of a plurality of T-wave amplitudes on corresponding heart rates for the follow-on ECG;
• and
• comparing the follow-on dependency with the baseline dependency.