Sensor For Detection Of Carbohydrate
AssigneeMedtronic MiniMed, Inc.
InventorsJesper Svennin Kristensen, Klaus Gregorius, Casper Struve, John Myhre Frederiksen, Yihua Yu
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Abstract
A sensor for the detection or measurement of carbohydrate analyte (such as glucose) in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal (such as FRET assay) retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising: an animal lectin; and an analyte analogue capable of competing with analyte for binding to the lectin.
Claims28
A sensor for the detection or measurement of carbohydrate analyte in fluid, the sensor comprising components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising:
- an animal lectin;
- and
- an analyte analogue capable of competing with analyte for binding to the lectin.
A sensor for the detection or measurement of a carbohydrate analyte in fluid, the sensor comprising components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising:
- a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair;
- and
- a carbohydrate analogue capable of competing with the 15 analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising:
- polymerized residues of monomer units, the first monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair;
- and/or co-polymerised residues of first monomer units and second monomer units, the first monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and the second monomer unit residues bearing pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
Dependencies are inferred from the claim text.