Process for Preparing Benzylated Amines
AssigneeMallinckrodt Inc.
InventorDennis J. Kalota
Life of this patent
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Abstract
This present invention relates to a process for preparing benzylated amines by the reaction of an amine selected from methamphetamine and propylhexedrine with benzyl halide. Numerous improvements are obtained by employing the amine in molar excess with respect to benzyl halide, preferably in a molar ratio of 2 to 1. The excess amine is employed to selectively neutralize by-product acid as the amine salt. The amine salt is then separated from the reaction mixture and basified to reclaim starting amine for recycle to the process.
Claims32
A process for the preparation of a benzylated amine with the co-production of by-product hydrogen halide, by the reaction of an amine selected from the group consisting of methamphetamine and propylhexedrine with a benzyl halide in a reaction vessel wherein said amine is in molar excess with respect to the benzyl halide and such excess reacts with by-product hydrogen halide to produce an amine halide.
A process for preparing benzphetamine with the co-production of by-product hydrogen chloride by the reaction of methamphetamine with benzyl chloride comprising the steps of:
- A) combining the methamphetamine with benzyl chloride in a molar ratio of about 2 to 1, respectively, in a reaction vessel to produce benzphetamine and by-product hydrogen chloride;
- B) allowing the excess methamphetamine to react with by-product hydrogen chloride to produce a reaction mixture containing benzphetamine and methamphetamine hydrochloride salt;
- C) separating said methamphetamine hydrochloride salt from the reaction mixture;
- D) basifying methamphetamine hydrochloride to provide methamphetamine and isolating said methamphetamine, then;
- E) recycling the methamphetamine of step D to step A.
A process for preparing N-benzylpropylhexedrine with the co-production of by-product hydrogen chloride by the reaction of propylhexedrine with benzyl chloride comprising the steps of:
- A) combining the propylhexedrine with a benzyl chloride in a reaction vessel in a molar ratio of about 2 to 1, respectively to produce N-benzylpropylhexedrine and by-product hydrogen chloride;
- B) allowing the excess propylhexedrine to react with by-product hydrogen chloride to produce propylhexedrine hydrochloride to produce a reaction mixture containing N-benzylpropylhexedrine and propylhexedrine hydrochloride salt;
- C) separating said propylhexedrine hydrochloride from the reaction mixture;
- D) basifying propylhexedrine hydrochloride to provide propylhexedrine and isolating said propylhexedrine, then;
- E) recycling the propylhexedrine of step D to step A.
Dependencies are inferred from the claim text.