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US 2008/0188656 A1Published application
Process for the Synthesis of 5- (Methyl-1H-Imidazol-1-Yl) -3- (Trifluoromethyl) -Benzeneamine
AssigneeNovartis AG
InventorsWen-Chung Shieh, Joseph McKenna
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Abstract
The present invention provides a new method of making compounds of formula (I): wherein R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and R4 is hydrogen, lower alkyl or halogen.
Claims7
A process for the preparation of compounds of formula (I)
- comprising reacting the compound:
- with R1—NH—R2, wherein
- R1 is substituted or unsubstituted aryl;
- R2 is hydrogen, lower alky or aryl;
- R4 is hydrogen, lower alkyl or halogen;
- and
- R3 is lower alkyl, phenyl, phenyl-lower alkyl or substituted phenyl,
- and wherein the process is catalyzed by a base in an organic solvent.
5 more elements
A process for the preparation of a compound of the formula (Ia)
- comprising reacting the compound:
- wherein R3 is lower alkyl, phenyl, phenyl-lower alkyl or substituted phenyl, with the compound 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine of the structure (IVa):
- and wherein the process is catalyzed by a base in an organic solvent.
A process for the preparation of a compound of the formula (Ia)
- comprising reacting the compound:
- with 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine (IVa) wherein the process is catalyzed by a base in an organic solvent.
Dependencies are inferred from the claim text.