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OwnerEnzo Paoletti, James Tartaglia +3inventors
InventorsEnzo Paoletti, James Tartaglia, William I. Cox, Robert Gallo, Genoveffa Franchini
Estimating the term…
Attenuated recombinant viruses containing DNA encoding an immunodeficiency virus and/or CTL antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: HIV1gag(+pro) (IIIB), gp120(MN) (+transmembrane), nef (BRU)CTL, pol(IIIB)CTL, ELDKWA or LDKW epitopes, preferably HIV1gag(+pro) (IIIB), gp120(MN) (+transmembrane), two (2) nef(BRU)CTL and three (3) pol(IIIB)CTL epitopes; or two ELDKWA in gp120 V3 or another region or in gp160. The two (2) nef(BRU)CTL and three (3) pol(IIIB)CTL epitopes are preferably CTL1, CTL2, pol1, pol2 and pol3. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. DNA from the recombinant viruses are useful as probes or, for generating PCR primers or for immunization. Also disclosed and claimed are HIV immunogens and modified gp160 and gp120.
1-35. (canceled)
A protein having an amino acid sequence comprising the amino acid sequence of HIV1 gp120, wherein the amino acid sequence of the gp120 is modified so as to contain an epitope not naturally occurring in HIV1 gp120.
The protein having the amino acid sequence identified as SEQ ID NO:
A nucleic acid molecule comprising the nucleic acid sequence which encodes the amino acid sequence identified as SEQ ID NO:
Dependencies are inferred from the claim text.