Drug delivery system
AssigneeIsis Innovation Limited
InventorDermot Michael O'Hare
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Abstract
A drug delivery system for the controlled release of a pharmaceutically-active compound by oral route comprises an intercalate of a layered double hydroxide having, before intercalation, layers of metal hydroxides, and having intercalated therein a pharmaceutically-active compound having at least one anionic group. A preferred layered double hydroxide is one that has layers which comprise [LiAl2(OH)6]+. The drug delivery system has use in the delivery of drugs such as 4-biphenylacetic acid, Diclofenac, Gemfibrozil, Ibuprofen, Naproxen, 2-Propylpentanoic acid and Tolfenamic acid.
Claims22
A drug delivery system comprising an intercalate of a layered double hydroxide having, before intercalation, layers of metal hydroxides, and having intercalated therein a pharmaceutically-active compound having at least one anionic group.
A method of making an intercalate of a layered double hydroxide having, intercalated therein, a pharmaceutical-active compound having at least one anionic group which comprises treating an aqueous solution of the pharmaceutically-active compound, optionally in the form of a non-toxic salt thereof, with the layered double hydroxide and separating the intercalate of the layered double hydroxide.
The method according to claim, wherein A is selected from OH, F, Cl, Br, I, SO4, and NO3.
Dependencies are inferred from the claim text.