Crystalline polymorphs of desvenlafaxine succinate and their preparations
AssigneeMai De Ltd.
InventorsCai Gu Huang, Hui Min He Huang
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Abstract
The present invention is directed to two new polymorph Form V and Form F of desvenlafaxine succinate, to processes of their preparations, pharmaceutical composition comprising such materials and their use in therapy. Form V is prepared from recrystallizing desvenlafaxine succinate in a mixture of tetrahydrofuran and ethanol. Form F is obtained from recrystallization of desvenlafaxine succinate in a mixture of cyclohexane and polar solvents such as ethanol, THF, methanol or isopropyl alcohol.
Claims21
Polymorph Form V of desvenlafaxine succinate.
Polymorph Form F of desvenlafaxine succinate.
A pharmaceutical composition comprising Form V or Form F of desvenlafaxine succinate and at least one or more pharmaceutically acceptable carrier, excipient, diluent, additive, filler, lubricant or binder.
A composition comprising (a) polymorph Form V or Form F of desvenlafaxine succinate and (b) a crystalline, hydrate, solvate, amorphous, polymorph Form I, Form II, Form III, Form VI or other polymorphic forms of desvenlafaxine succinate other than Form V or Form F, wherein the total weight of desvenlafaxine succinate in the composition is the sum of (a) and (b).
Dependencies are inferred from the claim text.