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AssigneeMedical Research Council
InventorsJonathan Joseph Powell, Sylvaine Francoise Bruggraber, Nuno Jorge Rodrigues Faria, Dora Isabel Amaral Pereira
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Ligand-modified poly oxo-hydroxy metal ion materials and their uses are disclosed, in particular for nutritional, medical, cosmetic or biologically related applications for example for the treatment of a deficiency related to a component of the material or for the removal of an endogenous substance capable of binding to the material. The present invention further relates to processes for preparing the materials and optimising their physico-chemical properties and their medical uses.
A process for producing a solid ligand-modified poly oxo-hydroxy metal ion material (MxLy(OH)n), wherein M represents one or more metal ions, L represents one or more ligands and OH represents oxo or hydroxy groups and n represents a polymeric structure, and wherein the gross solid ligand-modified poly oxo-hydroxy metal ion material has one or more reproducible physico-chemical properties and displays M-L bonding for at least one ligand that can be detected by physical analytical techniques,
The process of any one of the preceding claims, wherein the pH(A) is above a pH at which hydroxy polymerisation of the corresponding metal hydroxide commences.
The process of any one of the preceding claims, wherein the pH is changed from pH(A) to pH(B) by the addition of alkali.
The process of any one of the preceding claims, wherein the one or more reproducible physico-chemical properties are selected from dissolution (rate, pH dependence and pM dependence), adsorption and absorption characteristics, reactivity-inertness, melting point, temperature resistance, particle size, magnetism, electrical properties, density, light absorbing/reflecting properties, hardness-softness, colour and encapsulation properties.
The process of any one of the preceding claims, wherein the polymeric structure in which the M, L and oxo or hydroxy groups are distributed within the solid phase structure is such that the substitution of the oxo or hydroxy groups by the one or more ligands is substantially random.
The process of any one of the preceding claims, wherein the metal ion (M) is a Group 2, 3 or 5 metal ion, a transition metal ion, a heavy metal ion or a lanthanide ion.
The process of any one of the preceding claims, wherein the ligand species (L) is selected from a carboxylic acid such as glutaric acid, tartaric acid, malic acid, succinic acid and citric acid, a sugar such as maltol and ethyl maltol, an anion with ligand properties such as bicarbonate, sulphate and phosphate, a mineral ligand such as silicate, molybdate and selenate, an amino acid such as tryptophan, glutamine or histidine or a nutrient-based ligand such as folate, ascorbate or niacin.
The process of any one of the preceding claims, wherein the ligand has buffering properties or a buffer is present in a medium for carrying out the process.
The process of any one of the preceding claims, wherein the composition is for use an iron supplement.
A process for producing a solid ligand-modified poly oxo-hydroxy metal ion material and optimising a desired physico-chemical property of the material to adapt it for a nutritional, medical, cosmetic or biologically related application, wherein the solid ligand-modified poly oxo-hydroxy metal ion material is represented by the formula (MxLy(OH)n), wherein M represent one or more metal ions, L represents one or more ligands and OH represents oxo or hydroxy groups and n represents a polymeric structure, wherein the gross solid ligand-modified poly oxo-hydroxy metal ion material has one or more reproducible physico-chemical properties and displays M-L bonding for at least one ligand that can be detected by physical analytical techniques,
A composition for administration to a subject comprising a solid ligand-modified poly oxo-hydroxy metal ion material represented by the formula (MxLy(OH)n), wherein M represent one or more metal ions, L represents one or more ligands and OH represents oxo or hydroxy groups, wherein the composition is as obtainable by the process of any one of the preceding claims.
A ferric iron composition for administration to a subject which comprises a solid ligand-modified poly oxo-hydroxy metal ion material represented by the formula (MxLy(OH)n), wherein M represents one or more metal ions that comprise Fe3+ ions, L represents one or more ligands and OH represents oxo or hydroxy groups and n represents a polymeric structure in which the ligands L are substantially randomly substituted for the oxo or hydroxy groups, the solid polyhydroxy-metal ion-ligand material having one or more reproducible physico-chemical properties and demonstrable M-L bonding using physical analysis.
Dependencies are inferred from the claim text.