Uses of ion channel modulating compounds
AssigneeCardiome Pharma Corp.
InventorsGregory N. Beatch, Alan M. Ezrin
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Abstract
Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods, the disease or condition is treated or prevented by administering one or more ion channel modulating compounds to a subject, where the ion channel modulating compound or compounds produce specific plasma levels in the subject. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds.
Claims12
1-112. (canceled)
A method for preventing or postponing onset of arrhythmia in a human subject, the method comprising administering to the subject one or more doses of a formulation, wherein each dose of the formulation independently comprises an ion channel modulating compound of formula
- including isolated enantiomeric, diastereomeric and geometric isomers thereof and mixtures thereof, or a solvate or pharmaceutically acceptable salt thereof;
- wherein R4 and R5 are independently selected from hydrogen, hydroxy and C1-C6alkoxy;
- and
- wherein the total concentration of the ion channel modulating compound in the blood plasma of the subject has a mean trough concentration of greater than about 1 ng/ml and/or a steady state concentration of greater than about 1 ng/ml.
Dependencies are inferred from the claim text.