Pharmaceutical compositions containing substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)

A composition comprising a compound of formula (I), or a pharmaceutically acceptable salt, solvate or ester thereof:

• wherein:
• R1 is selected from C1-C8 alkyl, (—CH2)n—C3-C6 cycloalkyl, wherein n is an integer of from 0 to 3, pyridinyl, —CH2-pyridinyl, phenyl or benzyl, the rings of the cycloalkyl, pyridinyl, phenyl and benzyl groups being optionally substituted by, from 1 to 3 groups independently selected from halogen, C1-C4 alkyl, C1-C3 perfluoroalkyl, —O—C1-C3 perfluoroalkyl, C1-C3 alkoxy, —OH, —NH2, and —NO2;
• R2 is selected from H, C1-C6 alkyl, C3-C6 cycloalkyl, —CH2—C3-C6 cycloalkyl, or C1-C3 perfluoroalkyl, —CH2OH or CH2OAc;
• R3 is selected from H, halogen, C1-C6 alkyl, C1-C3 perfluoroalkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, —CH2—C3-C6 cycloalkyl, C3-C6 cycloalkenyl, —CH2—C3-C6 cycloalkenyl, —NH2, or —NO2;
• R4 is phenyl substituted by from 1 to 3 groups independently selected from halogen, C1-C4 alkyl, C1-C3 alkoxy, C1-C3 perfluoroalkyl, and —O—C1-C3 perfluoroalkyl;
• and
• from 1% to 25% w/w of one or more surfactants.