Novel indole polymorphs
AssigneeWyeth
InventorsAbdolsamad TADAYON, Hsueh-Ling Wu, Mannching Sherry Ku, David Zenan Li
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Abstract
Novel polymorphs, pharmaceutical compositions containing novel polymorphs, methods of using novel polymorphs and methods of preparing novel polymorphs of [1-(4-tert-Butylbenzyl)-5-(3-methylphenyl)-1H-indol-3-yl](oxo)acetic acid are described herein.
Claims55
A polymorph (Form A) of [1-(4-tert-Butylbenzyl)-5-(3-methylphenyl)1H-indol-3-yl](oxo)acetic acid having a powder X-ray diffraction pattern comprising characteristic peaks, in terms of 2θ, at about 6.5° and 10.9°.
A polymorph (Form A) of [1-(4-tert-Butylbenzyl)-5-(3-methylphenyl)1H-indol-3-yl](oxo)acetic acid having a differential scanning calorimetry trace showing a melting peak at about 138° C.;
- having onset about 134° C.
A polymorph (Form B) of [1 -(4-tert-Butylbenzyl)-5-(3-methylphenyl)1H-indol-3-yl](oxo)acetic acid having a powder X-ray diffraction pattern comprising characteristic peaks, in terms of 2θ, at about 5.2° and 25.6°.
A polymorph (Form B) of [1 -(4-tert-Butylbenzyl)-5-(3-methylphenyl)1H-indol-3-yl](oxo)acetic acid having a differential scanning calorimetry trace showing a melting peak at about 131° C.;
- having onset about 128° C.
A polymorph (Form C) of [1-(4-tert-Butylbenzyl)-5-(3-methylphenyl)1H-indol-3-yl](oxo)acetic acid having a powder X-ray diffraction pattern comprising characteristic peaks, in terms of 2θ, at about 5.4° and 6.8°.
A polymorph (Form C) of [1-(4-tert-Butylbenzyl)-5-(3-methylphenyl)1H-indol-3-yl](oxo)acetic acid having a differential scanning calorimetry trace showing a melting peak at about 82° C.;
- having onset about 74° C.
Dependencies are inferred from the claim text.