Thiazole Derivatives and Use Thereof

A thiazole derivative according to Formula (I),

• wherein R1 is selected from —C(O)R5, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, aryl C1-C6-alkyl, heteroaryl C1-C6-alkyl, C3-C8 cycloalkyl C1-C6-alkyl or heterocycloalkyl C1-C6-alkyl;
• R2 is selected from H, halogen, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl;
• R3 is selected from H, halogen, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl;
• R4 is selected from —C(O)R6, aryl, heteroaryl, heterocycloalkyl or C3-C8 cycloalkyl;
• R5 is selected from H, hydroxyl, alkoxy, amino, aryl, heteroaryl, C3-C8 cycloalkyl or heterocycloalkyl;
• R6 selected from H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, aryl C1-C6-alkyl, heteroaryl C1-C6-alkyl or amino;
• and
• X is selected from S or O;
• and isomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof.

A thiazole derivative according to Formula (Ia)

• wherein R1 is selected from —C(O)R5, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, aryl C1-C6-alkyl, heteroaryl C1-C6-alkyl, C3-C8 cycloalkyl C1-C6-alkyl or heterocycloalkyl C1-C6-alkyl
• R2 is selected from H, halogen, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl;
• R3 is selected from H, halogen, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl;
• R5 is selected from H, hydroxyl, alkoxy, amino, aryl, heteroaryl, C3-C8 cycloalkyl or heterocycloalkyl;
• X is selected from S or O;
• and isomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable thereof, with the proviso that the compounds of formula Ia are not the following compounds:
• [4,5′-Bithiazole]-2-acetonitrile, 2′-amino-4′-methyl;
• 2′-amino-4′-methyl-(phenylhydrazono)-[4,5′-Bithiazole]-2-acetonitrile;
• 2′-amino-[(4-chlorophenyl)hydrazono]-4′-methyl-[4,5′-Bithiazole]-2-acetonitrile;
• or
• [4,5′-Bithiazole]-4′-carboxylic acid, 2′-amino-2-methyl-, ethyl ester.