Cathepsin cysteine protease inhibitors

A compound of the following chemical formula:

• wherein
• R1 is hydrogen or C1-6 alkyl
• R2 is hydrogen or C1-6 alkyl
• or R1 and R2 can be taken together with the carbon atom to which they are attached to form a C3-8 cycloalkyl ring;
• R3 is C1-6 alkyl wherein said alkyl group is optionally substituted with one to six halo;
• R4 is hydrogen;
• R5 is hydrogen;
• R6 is C1-6 haloalkyl;
• each D is independently aryl or heteroaryl, wherein each said aryl or heteroaryl, is optionally substituted on either the carbon or the heteroatom with one to five substituents independently selected from C1-6 alkyl, haloalkyl or halo;
• R7 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkyloxy, halo, cyano, C3-8 cycloalkyl, heterocyclyl, C(R10)(R11)OH, —SR12, —SR9, SO(R12), —SOmN(Rc)(Rd), —SO2N(R10)C(O)(R12), N(R10)(R11), N(R10)CO(R9), —N(R10)C(O)R10, —N(R10)SO2(R10);
• wherein said groups are optionally substituted on either the carbon or the heteroatom with one to five substituents independently selected from C1-6 alkyl, halo, haloalkyl, hydroxyalkyl, —OR9, —NHS(O)2R8, —R9SO2R12, —SO2R12, —SO(R12), —SR12, —SR9, —SOmN(Rc)(Rd), —C(R10)(R11)OH, —COOH, N(R10)CO(R9), heterocycyl, aryl or heteroaryl;
• R8 is hydrogen;
• R9 is selected from the group consisting of hydrogen, aryl, aryl(C1-4)alkyl, heteroaryl, heteroaryl(C1-4)alkyl, C3-8cycloalkyl, C3-8cycloalkyl(C1-4)alkyl, and heterocyclyl(C1-4)alkyl wherein said groups can be optionally substituted with one, two, or three substituents independently selected from halo, alkoxy or —SO2R12;
• R10 is hydrogen or C1-6 alkyl
• R11 is hydrogen or C1-6 alkyl;
• R12 is hydrogen or C1-6 alkyl which is optionally substituted with one, two, or three substituents independently selected from halo, alkoxy, cyano, —NR10 or —SR10;
• Rc is hydrogen or C1-6 alkyl which is optionally substituted with one, two, or three substituents independently selected from halo or —OR9;
• Rd is hydrogen or C1-6 alkyl which is optionally substituted with one, two, or three substituents independently selected from halo or —OR9;
• or Rc and Rd can be taken together with the nitrogen atom to which they are attached or are between them to form a C3-8 heterocyclyl ring which is optionally substituted with one or two substituents independently selected from C1-6 alkyl, halo hydroxyalkyl, hydroxy, alkoxy or keto;
• n is independently selected from an integer from one to two;
• each m is independently selected from an integer from zero to one;
• and the pharmaceutically acceptable salts, stereoisomers and N-oxide derivatives thereof.