Methods of treating pain

A thiazole selected from the group consisting of:

• (±)-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-3-piperidinecarboxamide;
• (R)—N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazoly]-3-piperidinecarboxamide;
• (S)—N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazoly]-3-piperidinecarboxamide;
• cis-4-amino-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]cyclohexylcarboxamide;
• trans-4-amino-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]cyclohexylcarboxamide;
• N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-[[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]methyl]benzeneacetamide;
• N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl-4-[[(2-hydroxy-1,1-dimethylethyl)amino]methyl]benzeneacetamide;
• 4-[[(2,3-Dihydroxypropyl)amino]methyl]-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]benzeneacetamide;
• (R)-4-[[(2,3-Dihydroxypropyl)amino]methyl]-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]benzeneacetamide;
• (S)-4-[[(2,3-Dihydroxypropyl)amino]methyl]-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]benzeneacetamide;
• and
• a pharmaceutically acceptable salt thereof.

A pharmaceutical composition comprising at least one inhibitor of a cyclin-dependent kinase, wherein said at least one inhibitor is a thiazole characterized by any one of general Formula I, II or III:

• wherein
• R1 and R2 are independently hydrogen, fluorine or alkyl;
• R3 is aryl or heteroaryl;
• R4 is hydrogen, alkyl, cycloalkyl, aryl, cycloalkylalkyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl;
• or CO-alkyl, CO-cycloalkyl, CO-aryl, CO-alkyl-cycloalkyl, CO-alkyl-aryl, CO-heteroaryl, CO-alkyl-heteroaryl, CO-heterocycloalkyl, CO-alkyl-heterocycloalkyl;
• or CONH-alkyl, CONH-cycloalkyl, CONH-aryl, CONH-alkyl-cycloalkyl, CONH-alkyl-aryl, CONH-heteroaryl, CONH-alkyl-heteroaryl, CONH-heterocycloalkyl, CONH-alkyl-heterocycloalkyl;
• or COO-alkyl, COO-cycloalkyl, COO-aryl, COO-alkyl-cycloalkyl, COO-alkyl-aryl, COO-heteroaryl, COO-alkyl-heteroaryl, COO-heterocycloalkyl, COO-alkyl-heterocycloalkyl;
• or SO2-alkyl, SO2-cycloalkyl, SO2-aryl, SO2-alkyl-cycloalkyl, SO2-alkyl-aryl, SO2-heteroaryl, SO2-alkyl-heteroaryl, SO2-heterocycloalkyl, SO2-alkyl-heterocycloalkyl;
• or C(NCN)NH-alkyl, C(NCN)NH-cycloalkyl, C(NCN)NH-aryl, C(NCNNH)-alkyl-cycloalkyl, C(NCN)NH-alkyl-aryl, C(NCN)NH-heteroaryl, C(NCN)NH-alkyl-heteroaryl, C(NCN)NH-heterocycloalkyl, C(NCN)NH-alkyl-heterocylcoalkyl;
• or C(NNO2)NH-alkyl, C(NNO2)NH-cycloalkyl, C(NNO2)NH-aryl, C(NNO2)NH-alkyl-cycloalkyl, C(NNO2)NH-alkyl-aryl, C(NNO2)NH-heteroaryl, C(NNO2)NH-alkyl-heteroaryl, C(NNO2)NH-heterocyloalkyl, C(NNO2)NH-alkyl-heterocycloalkyl;
• or C(NH)NH-alkyl, C(NH)NH-cycloalkyl, C(NH)NH-aryl, C(NH)NH-alkyl-cycloalkyl, C(NH)NH-alkyl-aryI, C(NH)NH-heteroaryl, C(NH)NH-alkyl-heteroaryl, C(NH)NH-heterocycloalkyl, C(NH)NH-alkyl-heterocycloalkyl;
• or C(NH)NHCO-alkyl, C(NH)NHCO-cycloalkyl, C(NH)NHCO-aryl, C(NH)NHCO-alkyl-cycloalkyl, C(NH)NHCO-alkyl-aryl, C(NH)NHCO-heteroaryl, C(NH)NHCO-alkyl-heteroaryl, C(NH)NHCO-heterocylcloalkyl, C(NH)NHCO-alkyl-heterocycloalkyl;
• or C(NOR6)NH-alkyl, C(NOR6)NH-cycloalkyl, C(NOR6)NH-aryl, C(NOR6)NH-alkyl-cycloalkyl, C(NOR6)NH-alkyl-aryl, C(NOR6)NH-heteroaryl, C(NOR6)NH-alkyl-heteroaryl, C(NOR6)NH-heterocylcoalkyl, or C(NOR6)NH-alkyl-heterocycloalkyl;
• R5 is hydrogen or alkyl;
• R6 is hydrogen, alkyl, cycloalkyl, aryl, cycloalkylalkyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;
• R7 is alkyl;
• R8 is hydrogen or alkyl;
• R9 and R10 are each independently hydrogen, alkyl, substituted alkyl, cycloalkyl or substituted cycloalkyl;
• R11 is hydrogen or alkyl substituted with one or two hydroxyl groups or with an amino group;
• R15 is hydrogen or alkyl;
• or R15 and R11 taken together are —(CH2)q— where q is 3, 4, 5 or 6;
• R14 is hydrogen or alkyl;
• X is CH or N;
• Z is NR9 or CHNR9R10;
• m is 0, 1, or 2;
• n is 1, 2, or 3;
• E is a covalent bond or (CH2)p;
• and
• p is 1, 2 or 3;
• and enantiomers, diastereomers and pharmaceutically acceptable salts thereof.