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US 2008/0188520 A1Published application
Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them
AssigneeSanofi-Aventis
InventorsJoachim BRENDEL, Heinrich Christian ENGLERT, Stefan PEUKERT, Klaus WIRTH, Michael WAGNER, Jean-Marie RUXER, Fabienne PILORGE
Life of this patent
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Abstract
The invention relates to compounds of formula I in which A, R1, R2, R3, R4, R5, R6, R7 and n have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
Claims16
A compound of formula I,
- in which:
- A is C, S or S═O;
- n is 0, 1, 2 or 3;
- R1 is phenyl, pyridyl, thienyl, naphthyl, quinolinyl, pyrimidinyl or pyrazinyl,
- where each of these aryl radicals is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CN, alkoxy having 1, 2, 3 or 4 C atoms, OCF3, methylsulfonyl, CF3, alkyl having 1, 2, 3 or 4 C atoms, dimethylamino, sulfamoyl, acetyl, and methylsulfonylamino;
- or
- R1 is cycloalkyl having 3, 4, 5, 6 or 7 C atoms;
- R2 is phenyl, pyridyl, thienyl, naphthyl, quinolinyl, pyrimidinyl or pyrazinyl,
- where each of these aryl radicals is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CN, COOMe, CONH2, alkoxy having 1, 2, 3 or 4 C atoms, OCF3, OH, methylsulfonyl, CF3, alkyl having 1, 2, 3 or 4 C atoms, dimethylamino, sulfamoyl, acetyl, and methylsulfonylamino;
- R3 is CpH2p—R8;
- p is 0, 1, 2, 3, 4 or 5;
- R8 is CH3, CH2F, CHF2, CF3, cycloalkyl having 3, 4, 5, 6 or 7 C atoms, C≡CH, C≡C—CH3, alkoxy having 1, 2, 3 or 4 C atoms, phenyl or pyridyl,
- where phenyl and pyridyl are unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl having 1, 2, 3 or 4 C atoms, alkoxy having 1, 2, 3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
- R4 is hydrogen or alkyl having 1, 2 or 3 C atoms;
- R5 is hydrogen or alkyl having 1, 2 or 3 C atoms;
- R6 and R7
- are independently of one another hydrogen, F or alkyl having 1, 2, or 3 C atoms;
- and the pharmaceutically acceptable salts and trifluoroacetates thereof.
15 more elements
Dependencies are inferred from the claim text.