Imidazo [1,2-A] Pyridine Derivatives Useful As Peptide Deformylase (Pdf) Inhibitors

Compounds of formula (I)

• worin
• the radicals R1, R2, R3 and R4, independently of one another, are a hydrogen atom, a halogen atom, a hydroxy, amino, nitro or thiole group, an alkyl, alkenyl, alkinyt, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, hetero-alkylcycloalkyl, heterocycloalkyl, aralkyl or a heteroaralkyl radical, whereby all of these radicals may optionally be substituted, or two of the radicals R1, R2, R3 and R4 together may be part of a cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring, whereby each of these rings may optionally be substituted;
• R5 is a hydrogen atom, a halogen atom, a hydroxy, amino, nitro or thiole group, an alkyl, alkenyl, alkinyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl radical;
• the radicals R6 and R7, independently of one another, are a hydrogen atom, or an alkyl, alkenyl, alkinyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl radical, whereby all these radicals may optionally be substituted;
• and
• X is a group of formula —CS—NHOH, —CH2—CO—CH2—OH, —CO—CH2—OH, —CO—NHOH, —CNH—NHOH, —CH2—NOH—CHS, —NOH—CHS, —NOH—CHO, —CH2—NOH—CHO, —CH2—CHOH—CHO, —CHOH—CHO, —CHOH—COOH, —CH(CH2—OH)—COOH, —COOH or —CH2COOH, or is selected from the following formulae:
• whereby U is a bond, CH2, NH, O or S, V is O, S, NH or CH2, W is O, S, NH or CH2, and Y is OH or NH2, E is a bond, CH2, NH, O or S and the groups D, G and M, independently of one another, are N or CH, or a pharmaceutically acceptable salt, solvate, hydrate or a pharmaceutically acceptable formulation thereof.