Loading patent…
OwnerKhem Jhamandas, Tuan Tranginventors
Estimating the term…
Combination therapies of an opioid receptor agonist and a cannabinoid receptor antagonist in an amount effective to potentiate a therapeutic activity of the opioid receptor agonist and/or inhibit, delay, reduce and/or reverse tolerance to the opioid receptor agonist are provided. Also provided are methods for use of these combination therapies in potentiating a therapeutic activity of an opioid receptor agonist and/or inhibiting, delaying or reducing development of acute and/or chronic tolerance to opioid receptor agonists and treating conditions treatable by opioid receptor agonist therapy in a subject. In addition, a method for reversing opioid receptor agonist tolerance and/or restoring therapeutic effect of an opioid receptor agonist in a subject via administration of a cannabinoid receptor antagonist is provided.
A composition comprising an opioid receptor agonist in an amount effective to produce a therapeutic effect and a cannabinoid receptor antagonist in an amount effective to potentiate a therapeutic activity of an opioid receptor agonist and/or inhibit, delay, reduce and/or reverse tolerance to the opioid receptor agonist.
A method for potentiating a therapeutic activity of an opioid receptor agonist in a subject, the method comprising administering an opioid receptor agonist to the subject and administering a cannabinoid receptor antagonist to the subject in an amount effective to potentiate the therapeutic activity of the opioid receptor agonist and/or inhibit, delay, reduce and/or reverse tolerance to the opioid receptor agonist.
A method for inhibiting, delaying or reducing development of acute tolerance to a therapeutic effect of an opioid receptor agonist in a subject, the method comprising administering the opioid receptor agonist to the subject and administering a cannabinoid receptor antagonist to the subject.
A method for inhibiting, delaying or reducing development of chronic tolerance to a therapeutic effect of an opioid receptor agonist in a subject, the method comprising administering the opioid receptor agonist to the subject and administering a cannabinoid receptor antagonist to the subject.
A method for reversing tolerance to a therapeutic effect of an opioid receptor agonist or restoring a therapeutic effect of an opioid receptor agonist in a subject, the method comprising administering to the subject receiving opioid receptor agonist therapy a cannabinoid receptor antagonist.
A method for treating a subject suffering from a condition treatable with an opioid receptor agonist, the method comprising administering an opioid receptor agonist to the subject in an amount effective to produce a therapeutic effect and administering a cannabinoid receptor antagonist to the subject in an amount effective to potentiate a therapeutic activity of the opioid receptor agonist and/or inhibit, delay, reduce and/or reverse tolerance to the opioid receptor agonist.
A method for treating a subject suffering from a condition treatable with an opioid receptor agonist comprising administering to a subject receiving opioid receptor agonist therapy a cannabinoid receptor antagonist in an amount effective to potentiate a therapeutic activity of the opioid receptor agonist and/or inhibit, delay, reduce and/or reverse tolerance to the opioid receptor agonist.
Dependencies are inferred from the claim text.