Back to results
US 2008/0188483 A1Published application
Compounds and Compositions as Protein Kinase Inhibitors
AssigneeIrm LLC
InventorsPingda Ren, Nathanael Schiander Gray, Xia Wang, Guobao Zhang
Life of this patent
Estimating the term…
Abstract
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, BMX, BTK, CHK2, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK2α2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFRβ, PKA, PKBβ, PKD2, Rsk1, SAPK2α, SAPK2β, SAPK3, SGK, Tie2 and TrkB kinases.
Claims9
A compound of Formula I:
- in which:
- n is selected from 0, 1, 2, 3 and 4;
- Z1 is selected from N, C(O) and CR3;
- wherein R3 is selected from hydrogen, halo, C1-4alkyl, C1-4alkoxy, halo-substituted-C1-4alkyl, halo-substituted-C1-4alkoxy, C6-12aryl, C5-8heteroaryl, C3-12cycloalkyl, C3-8heterocycloalkyl and NR5R6;
- wherein R5 is independently selected from hydrogen and C1-4alkyl;
- and R6 is selected from hydrogen, C1-4alkyl and C6-12aryl;
- and wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R3 is optionally substituted with 1 to 3 radicals independently selected from hydrogen, halo, C1-4alkyl, C1-4alkoxy, halo-substituted-C1-4alkyl and halo-substituted-C1-4alkoxy;
- Z2 is selected from N and CR4;
- wherein R4 is selected from hydrogen, halo, C1-4alkyl, C1-4alkoxy, halo-substituted-C1-4alkyl, halo-substituted-C1-4alkoxy, C6-12aryl, C5-8heteroaryl, C3-12cycloalkyl, C3-8heterocycloalkyl and NR5R5;
- and wherein the bond between Z1 and Z2 is selected from a single bond and a double bond;
- R5 is independently selected from hydrogen and C1-4alkyl;
- and wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R4 is optionally substituted with 1 to 3 radicals independently selected from hydrogen, halo, C1-4alkyl, C1-4alkoxy, halo-substituted-C1-4alkyl and halo-substituted-C1-4alkoxy;
- R1 is selected from halo, C1-4alkyl and C1-4alkoxy;
- R2 is selected from NR5C(O)NR5R6, NR5C(O)R6, C(O)NR5R6, NR5S(O)0-2R6, S(O)0-2NR5R6 and NR5R6;
- wherein R5 is independently selected from hydrogen and C1-4alkyl;
- and R6 is selected from hydrogen, C1-4alkyl, C6-12aryl, C5-8heteroaryl, C3-12cycloalkyl and C3-8heterocycloalkyl;
- wherein any aryl, heteroaryl, cycloalkyl and heterocycloalkyl of R6 is optionally substituted by 1 to 3 radicals independently selected from halo, cyano, nitro, halo-substituted-C1-4alkyl, halo-substituted-C1-4alkoxy, C5-12heteroaryl-C0-4alkyl and C3-12heterocycloalkyl-C0-4alkyl;
- wherein any heteroaryl or heterocycloalkyl substituents of R6 can optionally be substituted by a radical independently selected from C1-4alkyl and C3-12heterocycloalkyl;
- and the pharmaceutically acceptable salts, hydrates, solvates and isomers thereof.
16 more elements
Dependencies are inferred from the claim text.