Use of Sildenafil, Vardenafil and Other 5-Phosphodiesterase Inhibitors to Enhance Permeability of the Abnormal Blood-Brain Barrier
AssigneeCedars-Sinai Medical Center
InventorKeith L. Black
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Abstract
This invention relates to compositions, methods and kits for enhancing the permeability of the blood-brain barrier. Particularly, compositions comprising 5-phosphodiesterase inhibitors, such as sildenafil, vardenafil, or tadalafil, when administered to a mammal, will selectively enhance the permeability of the blood-brain barrier in abnormal brain tissue. This selective enhancement allows for selective delivery of therapeutic agents to treat the abnormal brain tissue; for example, a brain tumor.
Claims36
A method to selectively enhance the permeability of the blood-brain barrier in abnormal brain tissue of a mammal, comprising:
- providing a 5-phosphodiesterase (“PDE-5”) inhibitor;
- and
- administering the PDE-5 inhibitor in an amount sufficient to selectively enhance the permeability of the blood-brain barrier of the mammal.
A method for treating abnormal brain tissue present in a mammal, comprising:
- providing a 5-phosphodiesterase (“PDE-5”) inhibitor;
- administering the PDE-5 inhibitor in an amount sufficient to selectively enhance the permeability of the blood-brain barrier in the mammal;
- and
- administering a therapeutic agent to the mammal.
A kit for selective enhancement of the permeability of the blood-brain barrier in a mammal, comprising:
- a quantity of a PDE-5 inhibitor;
- and
- instructions for using the kit to selectively enhance the permeability of the blood-brain barrier.
Dependencies are inferred from the claim text.