Dipeptidyl Peptidase-IV Inhibiting Compounds, Method Of Preparing The Same, And Pharmaceutical Compositions Containing The Same As An Active Agent

A compound of the following formula (1) or pharmaceutically acceptable salt thereof:

• wherein
• (A) A is selected from the group consisting of substituents of the following formulas (2) to (7):
• wherein R1 is hydrogen, or substituted or unsubstituted C1-C4 alkyl;
• and X is carbon or nitrogen;
• wherein R2 is hydrogen, or substituted or unsubstituted C1-C4 alkyl;
• wherein R3 is hydrogen, or substituted or unsubstituted C1-C4 alkyl, cycloalkyl, aryl or heteroaryl;
• and R′3 is hydrogen, or CF3;
• wherein R4 is hydrogen, halogen, or substituted or unsubstituted C1-C4alkyl, or selected from the substituents of the following formulas (6a) and (6b):
• wherein R5 is hydrogen, halogen, or substituted or unsubstituted C1-C4alkyl;
• and
• X is oxygen, sulfur, or sulfone;
• wherein R6 is halogen, or substituted or unsubstituted C1-C4alkyl;
• (B) B is selected from the group consisting of substituents of the following formulas (8) to (11):
• wherein R7, R8, R9 and R10 are each independently hydrogen, halogen, or substituted or unsubstituted C1-C4 alkyl;
• wherein R11, R12 and R13 are each independently hydrogen, halogen, or substituted or unsubstituted C1-C4 alkyl;
• and Y is oxygen, sulfur or SO2;
• wherein R14 and R15 are each independently hydrogen, halogen, or substituted or unsubstituted C1-C4 alkyl;
• and Z is —CH— or oxygen, where Z is oxygen, R14 is nothing;
• wherein R17 is substituted or unsubstituted C1-C4 alkyl.