Vaccination
AssigneeGlaxo Group Limited
InventorsLindy Louise Thomsen, John Philip Tite
Life of this patent
Estimating the term…
Abstract
The present invention relates to improvements in DNA vaccination and in particular, methods of vaccinating a mammal against disease states, and to the use of imidazo[4,5-c]quinolin-4-amine derivative adjuvants in the manufacture of medicaments for boosting previously vaccinated individuals.
Claims8
A method of vaccinating an individual comprising the steps of:
- (c) vaccinating the individual with a first vaccine composition on one or more occasions, characterised in that said vaccine comprises an antigen but does not comprise an imidazo[4,5-c]quinolin-4-amine derivative, and
- (d) after waiting an appropriate length of time, vaccinating the same individual one of more times with a second vaccine, characterised in that the second vaccine composition comprises the same antigen as the first vaccine, the second vaccine being administered with an imidazo[4,5-c]quinolin-4-amine derivative.
Use of an imidazo[4,5-c]quinolin-4-amine derivative and an antigen in the manufacture of a booster dose of a vaccine medicament for administration to an individual, characterised in that the individual previously received a priming dose of the vaccine medicament comprising the same antigen but which did not comprise an imidazo[4,5-c]quinolin-4-amine derivative.
A vaccine administration device comprising and antigen and an imidazo[4,5-c]quinolin-4-amine derivative, the device being packaged together with an instruction leaflet advising that the administration device is used to administer the vaccine composition only to individuals that had previously received a vaccine comprising the same antigen but which did not comprise an imidazo[4,5-c]quinolin-4-amine derivative.
A kit comprising a first vaccine composition and a second vaccine composition, wherein the first vaccine composition and the second composition contain the same antigen characterised in that the second vaccine composition comprises an imidazo[4,5-c]quinolin-4-amine derivative.
Dependencies are inferred from the claim text.